Thank you. /usr/local always seems iffy to me, but this is after years in linux making sure to make packages to install any software via package manager. The thing I liked about macport's /opt, which is actually something of a standard for non-pacakge-managed software in linux, is that it's relatively encapsulated away from the rest of the directory structure. But as long as it does a reasonable job of uninstalling everything in a package it should be fine.
Does Homebrew require XCode? If so then speed of package installs is insignificant by comparison. If not then I'll give it a try-- that would reduce the total time to build from 1 day to something less obnoxious. -Jonathan