For your wav file: Don't forget that a 16 bit file will be blown up to double size (32 bits) and will then take up 304 MB. It depends on your RAM size if that can be handled.
It would seem that the file takes up twice as much room even when only one track is being used? The story gets stranger and stranger!
Nothing strange here. All numbers in PD (signal or float) are represented in 32-bit floating point. So when you read data from a CD-quality soundfile (which is 16-bit integer) into memory, it is converted to 32-bit FP, and thus takes up twice as much space in RAM as on disk. If you were using, e.g., a 24-bit soundfile, it would only use 1.333... times as much space.
Jer