The configure.in for Miller's 0.39-2 (and CVS) makes the assumption that Darwin is always big endian and defines -DPA_BIG_ENDIAN. I manually changed the resulting makefile to the little endian flag for Pd to work. Also, I used the version of Tcl/Tk that comes with OSX which is in /System/Library/Frameworks/ so I changed that in the makefile as well.
cgc