We are trying libpd with Unity as suggested here:
https://github.com/playdots/UnityPd . We are on Macos Catalina. The problem sounds like sampling rate mismatch, or block size distortion, and only occurs when more than 2 channels (i.e., quad, surround 5.1, 7.1, etc) are set on both Unity and the Audio MIDI Setup. We are using a recent Motu interface, and everything is set to 44.1 (Pd, Unity, and macos preferences)