Is it running with the *same* OS and settings? It might be a scheduling issue with the kernel, realtime settings, crappy networking driver, etc. 

On Jan 30, 2018, at 12:00 PM, pd-list-request@lists.iem.at wrote:

From: Roman Haefeli <reduzent@gmail.com>
To: "pd-list@lists.iem.at" <pd-list@lists.iem.at>
Subject: Re: [PD] glitches when streaming UDP
Message-ID: <1517306864.2068.8.camel@gmail.com>
Content-Type: text/plain; charset="utf-8"

On Mon, 2018-01-29 at 10:25 +0100, Roman Haefeli wrote:

I'm working on a patch that transmits audio through UDP. The patch
runs
totally smooth on macOS (10.10 and 10.11) with Pd 0.48-1 and JACK as
back-end. On the Linux machines I tested (all Ubuntu 16.04) with the
same version of Pd I get a lot of glitches, although I'm using very
similar Jack settings (128 frames/period, 3 periods).

Update:
My personal, somewhat outdated laptop from 2007 has absolutely stable
performance with same patch, same Pd version, same OS, same kernel. To
be clear: It's only Pd that performs well on one computer and not so
well on others. I get glitch-free audio with Ardour on all tested
computers. So I wonder what circumstances affect specifically Pd. It's
a pity the most powerful computer I have access to is in its current
state not suitable for Pd projects :-(

Roman 

--------
Dan Wilcox
@danomatika
danomatika.com
robotcowboy.com