Chris and I have some ideas on this and it would not be very difficult, as opposed to either restarting Pd-extended or building an entirely new gui/app. We have a start but, I hate to sound like a broken record, neither he nor I have been able to put any time into it yet. Hopefully soon.
The basic ideas is a simple set of scripts which help you download rebuild library binaries or optional download and build the sources. As a start, they could be integrated into Vanilla as a gui plugin. Again, totally doable right now for an "extended" vanilla.