Why not?
I agree that its probably preferred to have matching architectures between Pd-core and Pd-GUI, but is it a requirement?
I would say yes.
afaict the problem lucarda is describing comes mostly from the fact that wish.exe and pdfontloader.dll have different archs. (or is this what you were saying).
Yes, that's what I was saying. If previous versions of the windows 64 bit build worked fine with a 64 bit pdfontloader, then it's because Pd game with a 64 bit tk, so it follows that is what's needed in this case.